Objective: To measure the validity and reliability of the Young Schema Questionnaire-Short Form (YSQ-SF) in Tibetan adolescents. Methods: Four questionnaires were translated from Chinese version to Chinese-Tibetan version. 435 middle school students were selected to complete the questionnaire YSQ-SF. Construct validity and internal consistency reliability were evaluated. 12 weeks later, 123 participants were randomly selected to complete the YSQ-SF, Children’s Automatic Thoughts Scale, Strength and Difficulties Questionnaire and the Short Mood and Feelings Questionnaire to calculate test-retest reliability and the criterion-related validity. Results: The internal consistency reliability for the total scale was 0.96, and for the factors ranged from 0.65 to 0.86. Confirmatory factor analysis confirmed the hypothesized 15-factor model (chi2/df = 1.39, Cn = 0.95, TLI = 0.94, RMSEA = 0.03). Test-retest reliability for the total scale was 0.67, and for die factors ranged from 0.37 to 0.57. AU the schemas scores were significantly positively correlated with the scores of the negative automatic thoughts, conduct problems and depression, and 14 schemas scores were significantly positively correlated with the scores of the hyperactivity except unrelenting standards; 10 schemas had significant negative correlation with the prosocial behaviors. Conclusion: The Chinese-Tibetan version of YSQ-SF has acceptable psychometric quality and can be used to assess the early maladaptive schemas in Tibetan adolescents.