Objective: To examine the reliability and validity of Chinese translation of The Strengths and Difficulties Questionnaire-self-report version (self-report SDQ). Methods: The questionnaire was administered to 832 adolescents. Mean and standard deviations of the self-report SDQ total scale and subscales were compared with the British normative samples (www.sdqinfo.com). Additionally, internal consistency, test-retest, criterion-related validity, and confirmatory factor analyses were analyzed. Results: The internal consistency reliability for the total scale was 0.81 and the eight-week test-retest reliability coefficient was 0.72. The item-subscale correlation coefficients ranged from 0.47 to 0.75. The subscales of SDQ had moderate to high correlation with corresponding subscales of YSR. And the results of confirmatory factor analyses (NNFI 0.91, CFI 0.92, RMSEA 0.043) indicated that the Five-factor structure of the self-report SDQ was suitable for the Chinese sample. Conclusion: The Chinese version of The Self-report Strengths and Difficulties Questionnaire with acceptable psychometric quality, can be applied to screen childhood psychopathology in China.