The aim of this review was to identify current issues affecting grandparents who are raising their grandchildren in Australia. The study systematically reviewed 12 studies that evaluated supports for grandparents. The Checklist Analysis of Research for Systematic Review and the Quantitative and Qualitative Checklist were used to evaluate the studies. Five support issues affecting grandparent-headed families were evidenced in the literature as being of priority. These include stress, intergenerational conflict, community support, legal and financial aspects, policies and service frameworks. The paucity of research implies that further funding for large-scale research is required. Implications for informal primary carers of grandchildren are that the lack of legal status and the sustained burden of care will continue to negatively impact upon the grandparents’ well-being. Further research to identify priorities and develop intervention strategies supported by policy development is required to enhance the health and well-being of grandparent carers and their grandchildren.