The parent-report Strengths and Difficulties Questionnaire (SDQ-P) is a widely used scale that assesses children’s and adolescents’ strengths and difficulties. The present study applied this scale to Italian adolescents and compared the current results with previous Chinese findings and the United Kingdom norm. Participants were 422 Italian parents and their adolescent children. Parents and adolescents answered the parent-report and the self-report SDQ, respectively. Results showed that the five-factor first-order model was better than other competing models. Cronbach’s alpha of emotional problems, conduct problems, hyperactivity, peer problems, prosocial behavior, and total difficulties was .63, .52, .69, .51, .59, and .77 respectively for mother-report measure, and .67, .48, .67, .46, .55, and .79 respectively for father-report measure. Parent-adolescent agreements ranged from low to medium, whereas mother-father agreements were large. Parents did not rate boys and girls as well as early-adolescence and mid-adolescence differently. Italian parents rated their adolescent children to have lower levels of hyperactivity, peer problems, total difficulties, and higher levels of prosocial behavior than Chinese parents; and Italian mothers rated their adolescent children to have lower levels of hyperactivity than United Kingdom parents. In conclusion, the current findings suggest both strengths and inadequacies of the SDQ-P for Italian adolescents.