Objective: Parental mental illness can lead to psychological problems and deteriorated health related quality of life of the children. In actual studies, psychological problems are more frequent and the health related quality of life in these children is worse compared to the general population. The CHIMPs (Children of mentally ill parents) study group developed an intervention program and its manual, that aims to reduce psychological problems and to improve the health related quality of life of the children. Method: In the present study (Intervention group n = 53, waiting list control group n = 14) psychological problems of the children from the therapist’s perspective are evaluated by the CBCL, SGKJ and BSS-K, changes of the health related quality of life of the children are evaluated by the KINDL-R from the patients’ and the children’s perspective before and after the intervention as well as one year after the end of the intervention. Results: The results of evaluation show, that psychological problems are reduced and health related quality of life is improved after the intervention. These improvements are stable over a period of one yean In the waiting list control group no significant improvements were detected. Conclusion: The results of evaluation of a specific intervention for the high risk group of children of psychiatrically ill parents show that the intervention is effective in reducing psychological problems and improving the health related quality of life of the children.