This study aimed to assess stress and self-perception of stress and stressful factors in caregivers of children with attention deficit hyperactivity disorder (ADHD). Participants were 40 caregivers, divided into: clinical group (G1)-20 caregivers of children diagnosed with ADHD; comparison group (G2)-20 caregivers of children without ADHD. The instruments used included the Strengths and Difficulties Questionnaire, Lipp’s Inventory of Stress Symptoms for Adults and the self-perceived Stress Questionnaire. Results point to a percentage of caregivers with stress indicators significantly higher in G1 than that found in G2 (p = 0.001). In G1, there was a greater perception of stress in the life with the child (p < 0.001), in the care of the child (p < 0.001), and an even greater perception of stress (p = 0.003) when compared to G2. The need to care for caregiver is noteworthy, since experiencing stress affects quality of life and the relationship and bonding between caregiver and child.